Figure 1. Metabolomics, heart disease and aging. Elderly subjects with heart disease show multi-organ impairment with significant metabolic alterations as confirmed by circulating metabolomics. Aging itself is characterized by metabolic changes in different organs including liver, muscle and adipose tissue resulting in a peculiar plasma metabolic profile (key changes are in fat and amino acid metabolism). Interestingly, the metabolic syndrome further affects the blood metabolome in the older subjects with alterations in amino acid metabolism being central features. Conversely, myocardial ischemic injury does not further alter the plasma metabolomic signature in old (and young) mice. Figure created with BioRender.com.