Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Yi Zhuo; Wei Chen; Wenshui Li; Yan Huang; Da Duan; Lite Ge; Jialin He; Jianyang Liu; Zhiping Hu; Ming Lu

doi:doi:10.18632/aging.202807

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Research Paper Volume 13, Issue 8 pp 11234—11256

Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke

Figure 6. IhOM-MSCs transplantation attenuates apoptotic cell death after ischemic stroke. (A) Improvement in cortical tissue structure and apoptosis marker Bax were evaluated by immunofluorescence. (B) The apoptosis marker Bax of nerve cells was detected by western blot analysis. (C) The apoptosis rate of nerve cells as evaluated by flow cytometry with Annexin V/PI staining. (OM-MSCs were replaced by MSCs in the figure. All data are presented as the mean value ± SD. *p<0.05, **p<0.01).