Research Paper Volume 13, Issue 8 pp 11296—11314

Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis

The hepcidin content is decreased in the postmenopausal women with osteoporosis. (A) Hepcidin concentration in the serum of peripheral blood in the postmenopausal women with osteoporosis (T score ≤ 2.5); (B) Lumbar BMD and serum hepcidin concentration showed a positive linear correlationship in the postmenopausal women with osteoporosis; r = 0.4560; statistical significance was considered at P = 0.0059, (n = 35; age = 62.11 ± 5.9).

Figure 1. The hepcidin content is decreased in the postmenopausal women with osteoporosis. (A) Hepcidin concentration in the serum of peripheral blood in the postmenopausal women with osteoporosis (T score ≤ 2.5); (B) Lumbar BMD and serum hepcidin concentration showed a positive linear correlationship in the postmenopausal women with osteoporosis; r = 0.4560; statistical significance was considered at P = 0.0059, (n = 35; age = 62.11 ± 5.9).