Research Paper Volume 13, Issue 8 pp 11296—11314

Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis


Figure 7. Mechanism pattern diagram of hepcidin overexpression to improve bone metabolism. Hepcidin overexpression in the model mice liver (1) reduces estrogen deficiency-induced bone loss (2), through reducing iron content (3), decreasing mitochondrial respiration (4) and ROS production (5), suppressing PGC-1β expression (6), inhibiting mitochondrial biogenesis (7), and depressing the function of osteoclasts (8).