Research Paper Volume 13, Issue 8 pp 11315—11335

lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury

Diagram depicting the signaling mechanisms of C2dat2 in CIRI. CIRI induces up-regulated C2dat2 to bind with HSC70/HSP90, blocks the RISC assembly, reduces the chaperone to load miR-30d-5p duplexes into Ago proteins, and inhibits the miR-30d-5p silencing of DDIT4 and then inhibits mTOR signaling pathway protein phosphorylation and facilitates neuronal autophagy and apoptosis.

Figure 8. Diagram depicting the signaling mechanisms of C2dat2 in CIRI. CIRI induces up-regulated C2dat2 to bind with HSC70/HSP90, blocks the RISC assembly, reduces the chaperone to load miR-30d-5p duplexes into Ago proteins, and inhibits the miR-30d-5p silencing of DDIT4 and then inhibits mTOR signaling pathway protein phosphorylation and facilitates neuronal autophagy and apoptosis.