Research Paper Volume 13, Issue 8 pp 11315—11335

lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury


Figure 8. Diagram depicting the signaling mechanisms of C2dat2 in CIRI. CIRI induces up-regulated C2dat2 to bind with HSC70/HSP90, blocks the RISC assembly, reduces the chaperone to load miR-30d-5p duplexes into Ago proteins, and inhibits the miR-30d-5p silencing of DDIT4 and then inhibits mTOR signaling pathway protein phosphorylation and facilitates neuronal autophagy and apoptosis.