Research Paper Volume 13, Issue 7 pp 10619—10658

Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight

Stratified Q-Q plots and fold-enrichment plots. Stratified Q-Q plots of nominal versus empirical -log10(p) values in T2D (A) as a function of the significance of the association with BW at the level of -log10(p) > 0, -log10(p) > 1, -log10(p) > 2, -log10(p) > 3 corresponding to p ≤ 1, p ≤ 0.1, p ≤ 0.01, p ≤ 0.001, and p ≤ 0.0001, respectively. and (B) reversely BW as a function of the significance of the association with T2D. Fold-enrichment plots of enrichment versus nominal -log10p-values (corrected for inflation) corresponding to levels of p ≤ 1, p ≤ 0.1, p ≤ 0.01, p ≤ 0.001, respectively in (C) T2D as a function of significance of the association with BW; and in (D) BW as a function of significance with T2D. Dashed lines indicate the null-hypothesis.

Figure 1. Stratified Q-Q plots and fold-enrichment plots. Stratified Q-Q plots of nominal versus empirical -log10(p) values in T2D (A) as a function of the significance of the association with BW at the level of -log10(p) > 0, -log10(p) > 1, -log10(p) > 2, -log10(p) > 3 corresponding to p ≤ 1, p ≤ 0.1, p ≤ 0.01, p ≤ 0.001, and p ≤ 0.0001, respectively. and (B) reversely BW as a function of the significance of the association with T2D. Fold-enrichment plots of enrichment versus nominal -log10p-values (corrected for inflation) corresponding to levels of p ≤ 1, p ≤ 0.1, p ≤ 0.01, p ≤ 0.001, respectively in (C) T2D as a function of significance of the association with BW; and in (D) BW as a function of significance with T2D. Dashed lines indicate the null-hypothesis.