Research Paper Volume 13, Issue 8 pp 11381—11410

Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma

Differential expression of interferon gamma response genes between tumor and normal tissues in the TCGA LUAD cohort. (A, B) Differential expression of interferon gamma response genes between tumor and normal tissues in the TCGA LUAD cohort is presented in the heatmap (A) and the box plot (B). ***PC) The mutation landscape of 24 interferon gamma response genes in 561 patients from the TCGA LUAD cohort. The middle panel depicts the gene mutation patterns across each sample with different mutation type colored differently. The mutation frequency in each gene is listed on the right of the middle panel, total mutation burden for each sample is shown in the upper barplot, the proportion of each mutation type of genes is shown on the right barplot. The fraction of nucleotide conversions in each sample is indicated by the stacked barplot below. (D) The correlation coefficient analysis of mutation co-occurrence in 24 interferon gamma response genes from the TCGA LUAD cohort.

Figure 1. Differential expression of interferon gamma response genes between tumor and normal tissues in the TCGA LUAD cohort. (A, B) Differential expression of interferon gamma response genes between tumor and normal tissues in the TCGA LUAD cohort is presented in the heatmap (A) and the box plot (B). ***P<0.001 (normal vs. tumor tissues). N, normal; T, tumor. (C) The mutation landscape of 24 interferon gamma response genes in 561 patients from the TCGA LUAD cohort. The middle panel depicts the gene mutation patterns across each sample with different mutation type colored differently. The mutation frequency in each gene is listed on the right of the middle panel, total mutation burden for each sample is shown in the upper barplot, the proportion of each mutation type of genes is shown on the right barplot. The fraction of nucleotide conversions in each sample is indicated by the stacked barplot below. (D) The correlation coefficient analysis of mutation co-occurrence in 24 interferon gamma response genes from the TCGA LUAD cohort.