Research Paper Volume 13, Issue 8 pp 11381—11410

Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma

Seven-gene risk signature can predict the prognosis in the TCGA LUAD cohort. (A) Kaplan-Meier curves of overall survival probability of the high vs. low risk group. (B) Risk score distribution in the TCGA LUAD cohort. (C) Survival time and survival status distribution in the TCGA LUAD cohort. (D) Heatmap showing the expression level for seven interferon gamma response genes among the high or low risk group in the TCGA LUAD cohort. (E, F) Univariate (E) and multivariate (F) Cox regression analysis of the association between clinicopathological features, the risk score, and patient overall survival confirmed the signature as an independent factor of patient overall survival in the TCGA LUAD cohort. (G) ROC curves for 3-year survival prediction and clinical characteristics, including age, gender, stage (T, N, or M) in the TCGA LUAD cohort. AUC, area under curve.

Figure 6. Seven-gene risk signature can predict the prognosis in the TCGA LUAD cohort. (A) Kaplan-Meier curves of overall survival probability of the high vs. low risk group. (B) Risk score distribution in the TCGA LUAD cohort. (C) Survival time and survival status distribution in the TCGA LUAD cohort. (D) Heatmap showing the expression level for seven interferon gamma response genes among the high or low risk group in the TCGA LUAD cohort. (E, F) Univariate (E) and multivariate (F) Cox regression analysis of the association between clinicopathological features, the risk score, and patient overall survival confirmed the signature as an independent factor of patient overall survival in the TCGA LUAD cohort. (G) ROC curves for 3-year survival prediction and clinical characteristics, including age, gender, stage (T, N, or M) in the TCGA LUAD cohort. AUC, area under curve.