Research Paper Volume 13, Issue 8 pp 11411—11432

Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation

TGLQ suppressed inflammatory cytokines in AS model ApoE-/- mice. (A–C) represent the expression levels of inflammatory cytokines including interleukin (IL)-6, IL-1β, and tumour necrosis factor (TNF)-α detected by ELISA kit respectively, in each group. The control group mice were fed with ordinary chow, while the mice of the model group, the low-dose TGLQ-prescription (LTGLQ) group and the high-dose TGLQ-prescription (HTGLQ) group were intragastrically injected with high-fat emulsion and stimulated with chronic stress. The LTGLQ and HTGLQ group mice were intragastrically injected with 8.775g/kg and 35.1g/kg TGLQ prescription daily respectively. #, ##, and ### represent P P P P P P P P P > 0.05.

Figure 7. TGLQ suppressed inflammatory cytokines in AS model ApoE-/- mice. (AC) represent the expression levels of inflammatory cytokines including interleukin (IL)-6, IL-1β, and tumour necrosis factor (TNF)-α detected by ELISA kit respectively, in each group. The control group mice were fed with ordinary chow, while the mice of the model group, the low-dose TGLQ-prescription (LTGLQ) group and the high-dose TGLQ-prescription (HTGLQ) group were intragastrically injected with high-fat emulsion and stimulated with chronic stress. The LTGLQ and HTGLQ group mice were intragastrically injected with 8.775g/kg and 35.1g/kg TGLQ prescription daily respectively. #, ##, and ### represent P < 0.05, P < 0.01, and P < 0.001 respectively, in comparison with the control group. *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001 respectively, in comparison with the model group. %% and %%% represent P < 0.01 and P < 0.001 respectively, in comparison with the LTGLQ group. n.s represents P > 0.05.