Review Volume 13, Issue 6 pp 9143—9151

The progeria research foundation 10th international scientific workshop; researching possibilities, ExTENding lives – webinar version scientific summary

At the PRF International Scientific Workshop, unpublished data were presented for treatment strategies that blanket the pathways upstream, at, and downstream of the disease-causing protein, progerin. Treatment targets: genetic and transcriptional shown in orange; post-translational processing shown in blue; disease effectors downstream of progerin shown in yellow. FT=farnesyltransferase; ICMT=Isoprenylcysteine Carboxyl Methyltransferase; INM=inner nuclear membrane; IL6R=interleukin 6 receptor; mTOR=mechanistic target of rapamycin.

Figure 2. At the PRF International Scientific Workshop, unpublished data were presented for treatment strategies that blanket the pathways upstream, at, and downstream of the disease-causing protein, progerin. Treatment targets: genetic and transcriptional shown in orange; post-translational processing shown in blue; disease effectors downstream of progerin shown in yellow. FT=farnesyltransferase; ICMT=Isoprenylcysteine Carboxyl Methyltransferase; INM=inner nuclear membrane; IL6R=interleukin 6 receptor; mTOR=mechanistic target of rapamycin.