Research Paper Volume 13, Issue 10 pp 13548—13559

Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model

Agomelatine restored the reduction of tight junction protein expressions in the MCAO mouse model. (A). Representative images of staining for claudin-5 in the cerebral cortex 3 days post-tMCAO; (B). Quantification of claudin-5 staining. Scale bar, 100 μM (****P ####P

Figure 3. Agomelatine restored the reduction of tight junction protein expressions in the MCAO mouse model. (A). Representative images of staining for claudin-5 in the cerebral cortex 3 days post-tMCAO; (B). Quantification of claudin-5 staining. Scale bar, 100 μM (****P < 0.0001 vs. vehicle group; ####P < 0.0001 vs. MCAO group).