Research Paper Volume 13, Issue 10 pp 13548—13559

Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model

Agomelatine reduced the expression and secretion of MCP-1 in hypoxic endothelial cells. Brain bEnd.3 endothelial cells were incubated with 10 μM Agomelatine in the process of hypoxia/ reperfusion (H/R). (A). mRNA of MCP-1 was measured; (B). Secretions of MCP-1 were measured (****P ####P

Figure 7. Agomelatine reduced the expression and secretion of MCP-1 in hypoxic endothelial cells. Brain bEnd.3 endothelial cells were incubated with 10 μM Agomelatine in the process of hypoxia/ reperfusion (H/R). (A). mRNA of MCP-1 was measured; (B). Secretions of MCP-1 were measured (****P < 0.0001 vs. vehicle group; ####P < 0.0001 vs. H/R group).