Research Paper Volume 13, Issue 8 pp 11470—11490

Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1

Inhibition of miR-1a improves the exercise ability in mice treated with statin. The protocol for animal experiments was shown in Figure 6A. (A, B): The levels of creatine kinase (CK) and lactate dehydrogenase (LDH) in plasma from mice were assayed. (C–F) The exercise capacity was determined, and the forelimb grip strength in (C) hanging grid time in (D) exhaustive running time in (E) and distance of exhaustive running in (F) were calculated. N is 10-15 in each group. **P #P##Ppost-hoc tests was used to determine P value in (A–F).

Figure 7. Inhibition of miR-1a improves the exercise ability in mice treated with statin. The protocol for animal experiments was shown in Figure 6A. (A, B): The levels of creatine kinase (CK) and lactate dehydrogenase (LDH) in plasma from mice were assayed. (CF) The exercise capacity was determined, and the forelimb grip strength in (C) hanging grid time in (D) exhaustive running time in (E) and distance of exhaustive running in (F) were calculated. N is 10-15 in each group. **P < 0.01 vs. PBS group. #P<0.05 or ##P<0.01 vs. statin alone. A one-way ANOVA followed by Tukey post-hoc tests was used to determine P value in (AF).