Research Paper Volume 13, Issue 6 pp 7998—8025

Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals

Selective pressure acting on autophagy-associated genes (n=274) in bat lineages. Results of tests for positive and divergent selection using the CodeML branch-site and clade model C models, conducted on the (A, C) the bat ancestor branch, (B, D) the vespertilionid ancestor. P values are transformed using −log10. Genes significant after FDR correction and appearing in both RefSeq and RefSeq+MAKER (including extra 8 species with highly fragmented genome assemblies) data sets are labelled above the red line, which indicates a significance cut-off of α = 0.05.

Figure 3. Selective pressure acting on autophagy-associated genes (n=274) in bat lineages. Results of tests for positive and divergent selection using the CodeML branch-site and clade model C models, conducted on the (A, C) the bat ancestor branch, (B, D) the vespertilionid ancestor. P values are transformed using −log10. Genes significant after FDR correction and appearing in both RefSeq and RefSeq+MAKER (including extra 8 species with highly fragmented genome assemblies) data sets are labelled above the red line, which indicates a significance cut-off of α = 0.05.