Research Paper Volume 13, Issue 8 pp 11629—11645

Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma

Hsa

Figure 3. Hsa_circ_0072309 reduction impaired tumorigenesis in cell lines. (A) Real-time qPCR shows the expression level of hsa_circ_0072309 in lung cancer cells H1975 and its knockdown efficiency. (B) Cell proliferation assays of hsa_circ_0072309-knockdown H1975 cells. (C) Invasion capability analysis of hsa_circ_0072309-knockdown H1975 cells by Transwell assays. (D) Migration ability analysis of hsa_circ_0072309-knockdown H1975 cells by wound-healing assays. (E) Real-time qPCR shows the expression level of hsa_circ_0072309 in lung cancer cells H1650 and its knockdown efficiency. (F) Cell proliferation assays of hsa_circ_0072309-knockdown H1650 cells. (G) Invasion capability analysis of hsa_circ_0072309-knockdown H1650 cells by Transwell assays. (H) Migration ability analysis of hsa_circ_0072309-knockdown H1650 cells by wound-healing assays. Quantitative results are indicated in the right panel (CD, GH). Student’s t-test (A, E). Two-way ANOVA followed by Tukey’s multiple comparisons test (BD, FH). *p < 0.05, **p < 0.01, ***p < 0.001.