Research Paper Volume 13, Issue 8 pp 11727—11737

MiR-27a-3p suppresses cerebral ischemia-reperfusion injury by targeting FOXO1

OGD-induced HT22 cell growth inhibition is significantly reversed by miR-27a-3p mimics. HT22 cells were transfected with mimics-control or miR-27a-3p mimics and then treated with OGD. (A) Expression of miR-27a-3p in HT22 cells detected with q-PCR. (B) Viability of HT22 cells assessed with CCK-8 assays. (C) Ki67 staining (red) showing proliferation of HT22 cells. Nuclei were counterstained with DAPI (blue). (D) Rate of Ki67 positivity. **P##P

Figure 1. OGD-induced HT22 cell growth inhibition is significantly reversed by miR-27a-3p mimics. HT22 cells were transfected with mimics-control or miR-27a-3p mimics and then treated with OGD. (A) Expression of miR-27a-3p in HT22 cells detected with q-PCR. (B) Viability of HT22 cells assessed with CCK-8 assays. (C) Ki67 staining (red) showing proliferation of HT22 cells. Nuclei were counterstained with DAPI (blue). (D) Rate of Ki67 positivity. **P<0.01 vs. control. ##P<0.01 vs. OGD.