Research Paper Volume 13, Issue 8 pp 11738—11751

Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models

Quercetin improves the neurochemical and parkinsonian disability score in 6-OHDA-lesioned PD rats. (A) Schema of the two part experiments. Rats were rated for rotarod test (B), forelimb function (C), and apomorphine induced contralateral rotation (D) (*P n = 8 for each group, two-way ANOVA test followed by Bonferroni’s post hoc test). Assessment of the oxidative markers with or without quercetin treatment in substantia nigra, such as MDA (E), ROS (F), and SOD (G) (n = 4 for each group). (H) The protein levels of TH and a-synuclein in different groups (n = 4 for each group). (I) Quantification of the TH protein level in each group. (J) Quantification of the a-synuclein protein level in each group. Data are expressed as mean ± SEM. *P

Figure 3. Quercetin improves the neurochemical and parkinsonian disability score in 6-OHDA-lesioned PD rats. (A) Schema of the two part experiments. Rats were rated for rotarod test (B), forelimb function (C), and apomorphine induced contralateral rotation (D) (*P < 0.05 compared to the designated control, n = 8 for each group, two-way ANOVA test followed by Bonferroni’s post hoc test). Assessment of the oxidative markers with or without quercetin treatment in substantia nigra, such as MDA (E), ROS (F), and SOD (G) (n = 4 for each group). (H) The protein levels of TH and a-synuclein in different groups (n = 4 for each group). (I) Quantification of the TH protein level in each group. (J) Quantification of the a-synuclein protein level in each group. Data are expressed as mean ± SEM. *P < 0.05 compared to the designated control (ANOVA followed by Dunnett's multiple-comparison post hoc tests).