Research Paper Volume 13, Issue 8 pp 11786—11807

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Identification of the DEGs between PT and PVTT tissues. Volcano plots showing the identification of the DEGs in (A) GSE69164, (B) GSE77509, and (C) GSE74656 datasets with the screening criteria of |log2(FC)| > 1 and P D) upregulated and (E) downregulated DEGs among the three datasets. Since no downregulated DEGs was identified in dataset GSE74656, the Venn diagram for it was not drawn. The expression of the 12 overlapping upregulated DEGs in PT and PVTT tissues in datasets (F) GSE69164, (G) GSE77509, and (H) GSE74656. DEGs, differentially expressed genes; PT, primary tumor; PVTT, portal vein tumor thrombus; FC, fold change.

Figure 1. Identification of the DEGs between PT and PVTT tissues. Volcano plots showing the identification of the DEGs in (A) GSE69164, (B) GSE77509, and (C) GSE74656 datasets with the screening criteria of |log2(FC)| > 1 and P < 0.05. Dots in red or green represent upregulated or downregulated DEGs in PT compared with PVTT tissues, dots in grey represent genes without significant expressional differences. Venn diagrams showing the intersections of (D) upregulated and (E) downregulated DEGs among the three datasets. Since no downregulated DEGs was identified in dataset GSE74656, the Venn diagram for it was not drawn. The expression of the 12 overlapping upregulated DEGs in PT and PVTT tissues in datasets (F) GSE69164, (G) GSE77509, and (H) GSE74656. DEGs, differentially expressed genes; PT, primary tumor; PVTT, portal vein tumor thrombus; FC, fold change.