Research Paper Volume 13, Issue 8 pp 11808—11821

Exosomes derived from miR-1228 overexpressing bone marrow-mesenchymal stem cells promote growth of gastric cancer cells

Overexpression of miR-1228 inhibits MMP-14 upregulation-induced growth and apoptosis of gastric cancer cells. (A, B) The proliferation of si-MMP-14 transfected cells was slowed down after co-culture, while that of sh-MMP-14 transfected cells was accelerated. (C) After co-culture, the apoptosis of si-MMP-14 transfected cells was accelerated and that of sh-MMP-14 transfected cells was slowed down. The apoptosis of sh-MMP-14+miR-1228-mimics transfected cells had no difference from that of si-NC transfected cells. aPvs. si-NC, bPvs. si-NC.

Figure 8. Overexpression of miR-1228 inhibits MMP-14 upregulation-induced growth and apoptosis of gastric cancer cells. (A, B) The proliferation of si-MMP-14 transfected cells was slowed down after co-culture, while that of sh-MMP-14 transfected cells was accelerated. (C) After co-culture, the apoptosis of si-MMP-14 transfected cells was accelerated and that of sh-MMP-14 transfected cells was slowed down. The apoptosis of sh-MMP-14+miR-1228-mimics transfected cells had no difference from that of si-NC transfected cells. aP< 0.05 vs. si-NC, bP< 0.01 vs. si-NC.