Research Paper Volume 13, Issue 10 pp 13585—13614

Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling

Cardiac remodeling validated by morphological and histological analysis. (A) Representative images of whole hearts and cross sections of hearts stained with hematoxylin-eosin staining (HE) and Masson's trichrome staining from different time points (scale bar = 2 mm). (B) Heart weight to body weight ratio (HW/BW). (C) Heart weight to tibia length ratio (HW/TL). (D) Lung weight to body weight ratio (LW/BW). (E) Lung weight to tibia length ratio (LW/TL); n = 8–10 at different time points. (F) Expression of the gene encoding ANP (atrial natrium peptide). (G) Expression of the gene encoding α-MHC (α-myosin heavy chain, Myh6). (H) Expression of β-MHC (Myh7); n = 6 at each time point. *P #P

Figure 6. Cardiac remodeling validated by morphological and histological analysis. (A) Representative images of whole hearts and cross sections of hearts stained with hematoxylin-eosin staining (HE) and Masson's trichrome staining from different time points (scale bar = 2 mm). (B) Heart weight to body weight ratio (HW/BW). (C) Heart weight to tibia length ratio (HW/TL). (D) Lung weight to body weight ratio (LW/BW). (E) Lung weight to tibia length ratio (LW/TL); n = 8–10 at different time points. (F) Expression of the gene encoding ANP (atrial natrium peptide). (G) Expression of the gene encoding α-MHC (α-myosin heavy chain, Myh6). (H) Expression of β-MHC (Myh7); n = 6 at each time point. *P < 0.05 vs. the corresponding time point in the sham group. #P < 0.05 compared with the prior time point in the MI group.