Figure 1. The mitochondria-LD interaction. In times of stress, the ER wraps around mitochondria and promotes mitochondrial fission. LDs originate from the ER and thus are in close contact to the OMM. A protein clamp stabilizes the contact between LDs and mitochondria and harmful proteins, protein aggregates as well as mitochondrial lipids (brown head group) are shuttled from mitochondria to LDs. LDs surrounded by a phospholipid monolayer (yellow head group) supply mitochondria with lipids (yellow) for beta-oxidation. OMM (outer mitochondrial membrane); IMM (inner mitochondrial membrane).