Research Paper Volume 13, Issue 8 pp 11877—11888

Overexpression of microRNA-202-3p in bone marrow mesenchymal stem cells improves cerebral ischemia-reperfusion injury by promoting angiogenesis and inhibiting inflammation

Detection of possible targeting molecules in vitro. (A–C) Overexpression of miR-202-3p could increase TLR4 expression, while si-TLR4 could reduce TLR4 expression. (D) si-TLR4 could reverse the effect of overexpression of miR-202-3p on the content of inflammatory factors in the supernatant of SH-SY5Y cells. (*compared with control, #compared with miR-202-3p, +compared with I/R + BMSCs-miR-202-3p, p

Figure 5. Detection of possible targeting molecules in vitro. (AC) Overexpression of miR-202-3p could increase TLR4 expression, while si-TLR4 could reduce TLR4 expression. (D) si-TLR4 could reverse the effect of overexpression of miR-202-3p on the content of inflammatory factors in the supernatant of SH-SY5Y cells. (*compared with control, #compared with miR-202-3p, +compared with I/R + BMSCs-miR-202-3p, p<0.05).