Research Paper Volume 13, Issue 10 pp 13644—13662

microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway

Regulatory mechanisms of miR-1246-containing EVs from AML cells involved in LSC bioactivities in AML. AML cells secreted EVs deliver miR-1246 to LSCs. MiR-1246 activates STAT3 pathway by targeting LRIG1, thereby promoting LSCs viability and colony formation and inhibiting cell apoptosis and differentiation, which ultimately elevates LSCs survival.

Figure 8. Regulatory mechanisms of miR-1246-containing EVs from AML cells involved in LSC bioactivities in AML. AML cells secreted EVs deliver miR-1246 to LSCs. MiR-1246 activates STAT3 pathway by targeting LRIG1, thereby promoting LSCs viability and colony formation and inhibiting cell apoptosis and differentiation, which ultimately elevates LSCs survival.