Research Paper Volume 13, Issue 7 pp 9373—9397

Differential role of melatonin in healthy brain aging: a systematic review and meta-analysis of the SAMP8 model

Risk of bias. (A) Overall RoB for each item in the SYRCLE tool for all included studies. Each RoB item is presented as a percentage based on all included studies. (B) Individual RoB for each of the included animal studies. Each item in the SYRCLE tool was scored as ‘yes’, ‘no’, or ‘unclear’.

Figure 3. Risk of bias. (A) Overall RoB for each item in the SYRCLE tool for all included studies. Each RoB item is presented as a percentage based on all included studies. (B) Individual RoB for each of the included animal studies. Each item in the SYRCLE tool was scored as ‘yes’, ‘no’, or ‘unclear’.