Research Paper Volume 13, Issue 8 pp 11919—11941

Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma

Expression of m6A regulators in ACC. (A) The process and molecular functions of m6A RNA methylation. (B) The expressive heatmap of m6A-related genes. The gene symbols are on the right of the heatmap. L, localized tumor (n = 46). M, metastatic tumor (n = 31). High expression is shown in red and low expression is green. (C–E) Differential expression of METTL3, HNRNPC and RBM15 between localized and metastatic tumor samples. Gene expression is measured by FPKM. FPKM, Fragments Per Kilobase per Million. *P **P

Figure 2. Expression of m6A regulators in ACC. (A) The process and molecular functions of m6A RNA methylation. (B) The expressive heatmap of m6A-related genes. The gene symbols are on the right of the heatmap. L, localized tumor (n = 46). M, metastatic tumor (n = 31). High expression is shown in red and low expression is green. (CE) Differential expression of METTL3, HNRNPC and RBM15 between localized and metastatic tumor samples. Gene expression is measured by FPKM. FPKM, Fragments Per Kilobase per Million. *P < 0.05, **P < 0.01.