Research Paper Volume 13, Issue 8 pp 11942—11953

Activation of GPR30 with G1 inhibits oscillatory shear stress-induced adhesion of THP-1 monocytes to HAECs by increasing KLF2

OSS reduced GPR30 expression in a frequency-dependent manner. HAECs were exposed to OSS (± 5 dyn/cm2) at frequencies of 0.5, 1.0, and 2.0 Hz for 12 h. (A). Expression of GPR30 at the mRNA level; (B). Expression of GPR30 at the protein level (*, #, $, P

Figure 2. OSS reduced GPR30 expression in a frequency-dependent manner. HAECs were exposed to OSS (± 5 dyn/cm2) at frequencies of 0.5, 1.0, and 2.0 Hz for 12 h. (A). Expression of GPR30 at the mRNA level; (B). Expression of GPR30 at the protein level (*, #, $, P<0.01 vs. previous column group, N=5).