Research Paper Volume 13, Issue 8 pp 12016—12030

Mendelian randomization as an approach to assess causal effects of inflammatory bowel disease on atrial fibrillation

Funnel plot of genetic associations with inflammatory bowel disease against causal estimates based on each genetic variant individually, where the causal effect is expressed in logs odds ratio of atrial fibrillation for each unit increase in inflammatory bowel disease. The overall causal estimates (β coefficients) of inflammatory bowel disease on atrial fibrillation estimated by inverse-variance weighted (short dash line) and MR-Egger (long dash line) methods are shown.

Figure 3. Funnel plot of genetic associations with inflammatory bowel disease against causal estimates based on each genetic variant individually, where the causal effect is expressed in logs odds ratio of atrial fibrillation for each unit increase in inflammatory bowel disease. The overall causal estimates (β coefficients) of inflammatory bowel disease on atrial fibrillation estimated by inverse-variance weighted (short dash line) and MR-Egger (long dash line) methods are shown.