Research Paper Volume 13, Issue 8 pp 12031—12045

Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats

Changes in the SIRT1/p53/p21 axis in osteogenic cells after LMV. (A) BMSCs were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3); (B) Osteoblasts were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3); (C) Osteocytes were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3). *P

Figure 8. Changes in the SIRT1/p53/p21 axis in osteogenic cells after LMV. (A) BMSCs were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3); (B) Osteoblasts were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3); (C) Osteocytes were treated with LMV and were harvested to detect the protein levels of SIRT1, p53, and p21 using western blotting (x¯±s,n=3). *P < 0.05 vs. old female rats.