Research Paper Volume 13, Issue 8 pp 12046—12057

Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells

MicroRNA-107 (miR-107) enhanced chemosensitivity in hepatocellular carcinoma (HCC) cells. (A) Knockdown of expression of miR-107 prevented HDACi (histone deacetylase inhibitor)-induced downregulation of cell viability in HA22T cells, as assessed with MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. (B) Upregulation of miR-107 enhanced chemosensitivity in HDACi-R cells, as assessed with MTT assay. Scramble miRNA group treated with 15 μM.

Figure 3. MicroRNA-107 (miR-107) enhanced chemosensitivity in hepatocellular carcinoma (HCC) cells. (A) Knockdown of expression of miR-107 prevented HDACi (histone deacetylase inhibitor)-induced downregulation of cell viability in HA22T cells, as assessed with MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. (B) Upregulation of miR-107 enhanced chemosensitivity in HDACi-R cells, as assessed with MTT assay. Scramble miRNA group treated with 15 μM.