Research Paper Volume 13, Issue 8 pp 12067—12085

Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells

Differential tumorigenic capacity and distinct expression profiles of miRNAs between pCRCSCs and pCRCSCs-derived differentiated cells. (A) pCRCSCs generated from a human colon cancer sample and their corresponding differentiated pCRCSCs. Bars = 200 μM. (B) A tumor-bearing nude mouse showing a large xenograft tumor from pCRCSCs (red oval) and a small tumor from pCRCSC-derived differentiated cells (green oval). (C) Tumor volume of the subcutaneous tumor generated from 5 × 105 pCRCSCs and differentiated pCRCSCs. (D) Weight of tumor-bearing mice. Bars represent mean ± standard deviation (SD) (n = 5, *p ***p E) Heat map of differentially expressed miRNAs in pCRCSCs and pCRCSC-derived differentiated cells.

Figure 2. Differential tumorigenic capacity and distinct expression profiles of miRNAs between pCRCSCs and pCRCSCs-derived differentiated cells. (A) pCRCSCs generated from a human colon cancer sample and their corresponding differentiated pCRCSCs. Bars = 200 μM. (B) A tumor-bearing nude mouse showing a large xenograft tumor from pCRCSCs (red oval) and a small tumor from pCRCSC-derived differentiated cells (green oval). (C) Tumor volume of the subcutaneous tumor generated from 5 × 105 pCRCSCs and differentiated pCRCSCs. (D) Weight of tumor-bearing mice. Bars represent mean ± standard deviation (SD) (n = 5, *p < 0.05, ***p < 0.001). (E) Heat map of differentially expressed miRNAs in pCRCSCs and pCRCSC-derived differentiated cells.