Research Paper Volume 13, Issue 9 pp 12493—12513

A novel gene signature for prognosis prediction and chemotherapy response in patients with pancreatic cancer

Gene set enrichment analysis (GSEA) and tumor immunity relevance of the gene signature. (A) GSEA for hallmark gene sets. Upregulated and downregulated enriched pathways with top normalized enrichment scores are shown. (B) Distribution of immune score in high and low risk groups in The Cancer Genome Atlas (TCGA) dataset. (C) Correlation of the infiltration proportion between different immunocytes. (D, E) Infiltration levels of different immunocytes in high and low risk groups. (F) Correlation between expression of programmed cell death protein 1 (PD-1) or epidermal growth factor receptor (EGFR) and risk score.

Figure 8. Gene set enrichment analysis (GSEA) and tumor immunity relevance of the gene signature. (A) GSEA for hallmark gene sets. Upregulated and downregulated enriched pathways with top normalized enrichment scores are shown. (B) Distribution of immune score in high and low risk groups in The Cancer Genome Atlas (TCGA) dataset. (C) Correlation of the infiltration proportion between different immunocytes. (D, E) Infiltration levels of different immunocytes in high and low risk groups. (F) Correlation between expression of programmed cell death protein 1 (PD-1) or epidermal growth factor receptor (EGFR) and risk score.