Research Paper Volume 13, Issue 9 pp 12537—12551

Silencing long noncoding RNA NEAT1 alleviates acute liver failure via the EZH2-mediated microRNA-139/PUMA axis

D-GalN/LPS induced ALF in the mouse model. (A) Survival curve of mice receiving i.p. injection of D-GalN and LPS within 12 h. (B) Histological analysis of liver tissues with H&E staining. (C) Biochemical analysis to detect the activity of ALT and ALF in serum samples collected from ALF mice and control mice. Data were summarized as mean ± S.D. from at least 3 independent biological replicates. * indicates p t-test. n = 12 mice for each group.

Figure 1. D-GalN/LPS induced ALF in the mouse model. (A) Survival curve of mice receiving i.p. injection of D-GalN and LPS within 12 h. (B) Histological analysis of liver tissues with H&E staining. (C) Biochemical analysis to detect the activity of ALT and ALF in serum samples collected from ALF mice and control mice. Data were summarized as mean ± S.D. from at least 3 independent biological replicates. * indicates p < 0.05. Data were compared using the unpaired student’s t-test. n = 12 mice for each group.