Research Paper Volume 13, Issue 9 pp 12607—12630

Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network

Prediction of miRNA-target interactions and ceRNA pairs, and construction of a circRNA-miRNA-mRNA ceRNA regulatory network. (A) MiRNA-circRNA interactions were filtered based on the miRNA-circRNA correlation coefficients and the miRNA-circRNA target pairs. (B) MiRNA-mRNA interactions were filtered based on the miRNA-mRNA correlation coefficients and the miRNA-mRNA target pairs. (C) Filtered miRNA-target interactions were integrated into circRNA-mRNA pairs (ceRNA pairs) based on shared miRNAs. CeRNA pairs were further filtered based on the ceRNA scores and the mRNA-circRNA correlation coefficients. (D) The ceRNA network. Yellow V-shaped nodes represent DECs, red rectangular nodes represent DEMis, and blue circular nodes represent DEMs. Larger nodes in the ceRNA network represent genes with higher degrees of connectivity.

Figure 4. Prediction of miRNA-target interactions and ceRNA pairs, and construction of a circRNA-miRNA-mRNA ceRNA regulatory network. (A) MiRNA-circRNA interactions were filtered based on the miRNA-circRNA correlation coefficients and the miRNA-circRNA target pairs. (B) MiRNA-mRNA interactions were filtered based on the miRNA-mRNA correlation coefficients and the miRNA-mRNA target pairs. (C) Filtered miRNA-target interactions were integrated into circRNA-mRNA pairs (ceRNA pairs) based on shared miRNAs. CeRNA pairs were further filtered based on the ceRNA scores and the mRNA-circRNA correlation coefficients. (D) The ceRNA network. Yellow V-shaped nodes represent DECs, red rectangular nodes represent DEMis, and blue circular nodes represent DEMs. Larger nodes in the ceRNA network represent genes with higher degrees of connectivity.