Research Paper Volume 13, Issue 9 pp 12800—12816

Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Decreased apoptosis in the IA arteries of rADAMTS-5-administered mice. (A) Representative images of TUNEL staining indicating less apoptosis (displayed in red) in arteries from rADAMTS-5-administered mice than in those from control (CTRL) mice. (B) Quantification of the TUNEL (+) cells in arteries from the control (CTRL) mice and rADAMTS-5-administered mice. **P

Figure 5. Decreased apoptosis in the IA arteries of rADAMTS-5-administered mice. (A) Representative images of TUNEL staining indicating less apoptosis (displayed in red) in arteries from rADAMTS-5-administered mice than in those from control (CTRL) mice. (B) Quantification of the TUNEL (+) cells in arteries from the control (CTRL) mice and rADAMTS-5-administered mice. **P<0.01.