Research Paper Volume 13, Issue 9 pp 12800—12816

Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Effects of rADAMTS-5 on proteolysis and detection of the main proteoglycans in IA arteries. Representative immunofluorescence staining images showing (A) versican (VCAN) degradation and (B) aggrecan (ACAN) degradation in IA arteries from sham mice and control (CTRL) mice and in arteries from rADAMTS-5-administered mice. Images in columns 3 and 5 represent higher magnification views of the areas contained within the white boxes in the left-hand columns. Versican and aggrecan are displayed in red, and the neoepitopes of versican and aggrecan are displayed in green. Scale bar: 25 μm.

Figure 6. Effects of rADAMTS-5 on proteolysis and detection of the main proteoglycans in IA arteries. Representative immunofluorescence staining images showing (A) versican (VCAN) degradation and (B) aggrecan (ACAN) degradation in IA arteries from sham mice and control (CTRL) mice and in arteries from rADAMTS-5-administered mice. Images in columns 3 and 5 represent higher magnification views of the areas contained within the white boxes in the left-hand columns. Versican and aggrecan are displayed in red, and the neoepitopes of versican and aggrecan are displayed in green. Scale bar: 25 μm.