Research Paper Volume 13, Issue 9 pp 12865—12895

Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma

Relationship between the identified risk signature and tumor immune cell infiltration based on the ICGC-LIRI-JP cohort. (A) The landscape of immune infiltration in each of the tumor samples of low- and high-risk groups. (B) Heatmap representing the correlation matrix of the four signature genes, risk score, and relative abundance of 22 immune cell types. Red indicates the positive correlation, while green indicates the negative correlation. * P P

Figure 10. Relationship between the identified risk signature and tumor immune cell infiltration based on the ICGC-LIRI-JP cohort. (A) The landscape of immune infiltration in each of the tumor samples of low- and high-risk groups. (B) Heatmap representing the correlation matrix of the four signature genes, risk score, and relative abundance of 22 immune cell types. Red indicates the positive correlation, while green indicates the negative correlation. * P < 0.05, ** P < 0.01.