Research Paper Volume 13, Issue 9 pp 12865—12895

Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma

Network pharmacological analysis to identify candidate drugs and effective compounds for therapeutic targets of HCV-HCC. (A) Drug-hub gene network identified from the DGIdb. Green nodes indicate the predictive miRNAs and red nodes indicate the targeted hub genes. (B) Herb-compounds-hub gene network predicted by TCM-MESH and TCM-ID. red nodes indicate hub genes, blue nodes indicate the active compounds and green nodes indicate the putative herbs containing these compounds.

Figure 12. Network pharmacological analysis to identify candidate drugs and effective compounds for therapeutic targets of HCV-HCC. (A) Drug-hub gene network identified from the DGIdb. Green nodes indicate the predictive miRNAs and red nodes indicate the targeted hub genes. (B) Herb-compounds-hub gene network predicted by TCM-MESH and TCM-ID. red nodes indicate hub genes, blue nodes indicate the active compounds and green nodes indicate the putative herbs containing these compounds.