Research Paper Volume 13, Issue 9 pp 12865—12895

Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma


Figure 6. Confirmation of the abnormal expression of the 10 selected hub genes and their expression correlations. (A, B) Two external datasets (GSE69715 and GSE12941) to validate the increased expression levels of the hub genes in tumors compared with adjacent normal tissues. (C) Internal validation by ICGC-LIRI-JP dataset to verify the elevated levels of the hub genes concerning tumor stage. (D, E) Strong correlations among all of the hub genes according to the ICGC-LIRI-JP and TCGA-LIHC datasets. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.