Research Paper Volume 13, Issue 10 pp 13739—13763

Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma

Phospho-ETS1 expression is associated with tumor stage. (A) Immunohistochemical staining of phospho-ETS1 and MMP-9 in ovarian cancer tissues. Tissue with high and low expressed phospho-ETS1 are shown in the upper and lower panels, respectively. (B) Advanced-stage malignancies (stages 3−4) showed a higher immunohistochemical expression of phospho-ETS1 as compared with early-stages tumors (stages 1−2) both in serous (black square) and endometrioid (black triangle) ovarian carcinomas. Asterisks in B denote statistical significance (*p C) and recurrence-free survival (D) in endometrioid type ovarian cancer patients (n = 29) were constructed according to phospho-ETS1 histoscores. The optimal cutoff for phospho-ETS1 histoscore in the prediction of overall survival and recurrence-free survival was 20.

Figure 6. Phospho-ETS1 expression is associated with tumor stage. (A) Immunohistochemical staining of phospho-ETS1 and MMP-9 in ovarian cancer tissues. Tissue with high and low expressed phospho-ETS1 are shown in the upper and lower panels, respectively. (B) Advanced-stage malignancies (stages 3−4) showed a higher immunohistochemical expression of phospho-ETS1 as compared with early-stages tumors (stages 1−2) both in serous (black square) and endometrioid (black triangle) ovarian carcinomas. Asterisks in B denote statistical significance (*p < 0.05). Kaplan-Meier plots of overall (C) and recurrence-free survival (D) in endometrioid type ovarian cancer patients (n = 29) were constructed according to phospho-ETS1 histoscores. The optimal cutoff for phospho-ETS1 histoscore in the prediction of overall survival and recurrence-free survival was 20.