Research Paper Volume 13, Issue 10 pp 13739—13763

Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma


Figure 7. Schematic representation of the role played by the GSK3β/ETS1/MMP-9 axis in cell migration. (A) Summary of the interactions between different GSK3β and ETS1 domains. (B) Upon phosphorylation by GSK3β, ETS1 interacts with p300 to activate the MMP-9 promoter. Inhibition of GSK3β activity results in ETS1 degradation.