Research Paper Volume 13, Issue 8 pp 10955—10972

Hyperbaric oxygen therapy effectively alleviates D-galactose-induced-age-related cardiac dysfunction via attenuating mitochondrial dysfunction in pre-diabetic rats

Effect of HBOT on mitochondrial dynamics parameters in cardiomyocytes of pre-diabetic rats after induction of aging by D-gal. (A) Mitochondrial MFN1 level. (B) Mitochondrial MFN2 level. (C) Phosphorylated Drp1 at serine 616 in cytosol. (D) Mitochondrial Drp1 level. NDV, normal diet fed rats with vehicle; NDDg, normal diet fed rats with D-gal; HFV, high-fat diet fed rats with vehicle; HFDg, high-fat diet fed rats with D-gal; MFN1, mitofusin 1; MFN2, mitofusin 2; Drp1, dynamin-related protein 1; VDAC, voltage-dependent anion channels; HBOT, hyperbaric oxygen therapy. (n = 5/group). *P

Figure 8. Effect of HBOT on mitochondrial dynamics parameters in cardiomyocytes of pre-diabetic rats after induction of aging by D-gal. (A) Mitochondrial MFN1 level. (B) Mitochondrial MFN2 level. (C) Phosphorylated Drp1 at serine 616 in cytosol. (D) Mitochondrial Drp1 level. NDV, normal diet fed rats with vehicle; NDDg, normal diet fed rats with D-gal; HFV, high-fat diet fed rats with vehicle; HFDg, high-fat diet fed rats with D-gal; MFN1, mitofusin 1; MFN2, mitofusin 2; Drp1, dynamin-related protein 1; VDAC, voltage-dependent anion channels; HBOT, hyperbaric oxygen therapy. (n = 5/group). *P < 0.05 compared to other groups.