Hyperbaric oxygen therapy effectively alleviates D-galactose-induced-age-related cardiac dysfunction via attenuating mitochondrial dysfunction in pre-diabetic rats

Cherry Bo-Htay; Thazin Shwe; Thidarat Jaiwongkam; Sasiwan Kerdphoo; Wasana Pratchayasakul; Thienchai Pattarasakulchai; Krekwit Shinlapawittayatorn; Siriporn C. Chattipakorn; Nipon Chattipakorn

doi:doi:10.18632/aging.202970

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Research Paper Volume 13, Issue 8 pp 10955—10972

Hyperbaric oxygen therapy effectively alleviates D-galactose-induced-age-related cardiac dysfunction via attenuating mitochondrial dysfunction in pre-diabetic rats

Figure 8. Effect of HBOT on mitochondrial dynamics parameters in cardiomyocytes of pre-diabetic rats after induction of aging by D-gal. (A) Mitochondrial MFN1 level. (B) Mitochondrial MFN2 level. (C) Phosphorylated Drp1 at serine 616 in cytosol. (D) Mitochondrial Drp1 level. NDV, normal diet fed rats with vehicle; NDDg, normal diet fed rats with D-gal; HFV, high-fat diet fed rats with vehicle; HFDg, high-fat diet fed rats with D-gal; MFN1, mitofusin 1; MFN2, mitofusin 2; Drp1, dynamin-related protein 1; VDAC, voltage-dependent anion channels; HBOT, hyperbaric oxygen therapy. (n = 5/group). ^*P < 0.05 compared to other groups.