Research Paper Volume 13, Issue 10 pp 13788—13806

Redd1 knockdown prevents doxorubicin-induced cardiac senescence

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Figure 1.

Cardiac Redd1 expression increases with advancing age. (A, B) Representative photomicrographs and quantitative analysis of myocardial p16INK4a immunofluorescent staining in young group mice (3~4 months old) and old group mice (24 months old) (n = 6 per group). (C, D) Representative photomicrographs of myocardial p21 immunofluorescent staining and quantitative expression analysis in young group mice and old group mice (n = 6 per group). (E, F) Western blotting detection and quantification of Redd1, p16INK4a, and p21 protein expression in the heart of young group mice and old group mice (n = 6–8 per group). Data are mean ± SEM. *p < 0.05 vs. young group.