Research Paper Volume 13, Issue 9 pp 12996—13005

Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2

Azilsartan reduced the expression of LOX-1 in HUVECs. Cells were stimulated with ox-LDL (100 μg/mL) in the presence or absence of Azilsartan (3, 6 μM) for 24 hours. (A) Gene expression of LOX-1; (B) Protein of LOX-1 (****, P

Figure 2. Azilsartan reduced the expression of LOX-1 in HUVECs. Cells were stimulated with ox-LDL (100 μg/mL) in the presence or absence of Azilsartan (3, 6 μM) for 24 hours. (A) Gene expression of LOX-1; (B) Protein of LOX-1 (****, P<0.0001 vs. vehicle group; ##, ###, P<0.01, 0.001 vs. ox-LDL group, N=6 for each group).