Research Paper Volume 13, Issue 9 pp 13006—13022

A preclinical study: correlation between PD-L1 PET imaging and the prediction of therapy efficacy of MC38 tumor with 68Ga-labeled PD-L1 targeted nanobody

The expression of CD39, CD103, and CD8 were tested by immunofluorescence of MC38 tumors (n=3, Scale bar=1000 μm). (A) MC38-hPD-L1 control (B) MC38-hPD-L1 (C) MC38-hPD-L1/KO (D) MC38-KO CD8 was indicated by red signals; CD39 or CD103 was indicated by green signals; nuclei, blue 4’,6-diamidino-2-phenylindole (DAPI) signals. Local amplifies the area indicated by the white box. Scale bar=200 μm.

Figure 7. The expression of CD39, CD103, and CD8 were tested by immunofluorescence of MC38 tumors (n=3, Scale bar=1000 μm). (A) MC38-hPD-L1 control (B) MC38-hPD-L1 (C) MC38-hPD-L1/KO (D) MC38-KO CD8 was indicated by red signals; CD39 or CD103 was indicated by green signals; nuclei, blue 4’,6-diamidino-2-phenylindole (DAPI) signals. Local amplifies the area indicated by the white box. Scale bar=200 μm.