Research Paper Advance Articles

Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells

CDK9 inhibitor reduces indices of atherosclerotic lesions in ApoE-/- mice fed with HFD. (A–B) Representative en face Oil Red O staining and quantification of Oil Red O-positive lipid area in the aorta (n = 8; ###p ***p C) Photomicrographs showing representative H&E staining of atherosclerotic lesions (scale bar = 500 μm). (D) Oil Red O staining of atherosclerotic lesions in the aortic root (scale bar = 500 μm) and quantification lesions area highlighted by Oil Red O staining. (E) Representative images of Masson’s Trichome staining for collagen deposition (scale bar = 50 μm). (F) Serum levels of TG, TC, LDL and HDL (n = 8; #P ##P ###p *P **P

Figure 2. CDK9 inhibitor reduces indices of atherosclerotic lesions in ApoE-/- mice fed with HFD. (AB) Representative en face Oil Red O staining and quantification of Oil Red O-positive lipid area in the aorta (n = 8; ###p < 0.001 compared to STD, ***p < 0.001 compared to HFD;). (C) Photomicrographs showing representative H&E staining of atherosclerotic lesions (scale bar = 500 μm). (D) Oil Red O staining of atherosclerotic lesions in the aortic root (scale bar = 500 μm) and quantification lesions area highlighted by Oil Red O staining. (E) Representative images of Masson’s Trichome staining for collagen deposition (scale bar = 50 μm). (F) Serum levels of TG, TC, LDL and HDL (n = 8; #P < 0.05, ##P < 0.01 and ###p < 0.001 compared to STD; *P < 0.05, **P < 0.01 compared to HFD).