Research Paper Volume 13, Issue 9 pp 13225—13238

TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways

Knockdown of TRIM14 inhibited melanoma cell proliferation. Both WM451 and A375 cells were transfected with siRNA-NC and siRNA-TRIM14-1/2, then the protein expression of TRIM14 in each group was measured using western blot (A–B). After transfection, the cell proliferation was determined using CCK-8 assay (C–D) and clone formation assay (E). *, **, ***p

Figure 2. Knockdown of TRIM14 inhibited melanoma cell proliferation. Both WM451 and A375 cells were transfected with siRNA-NC and siRNA-TRIM14-1/2, then the protein expression of TRIM14 in each group was measured using western blot (AB). After transfection, the cell proliferation was determined using CCK-8 assay (CD) and clone formation assay (E). *, **, ***p < 0.05, 0.01, 0.001 vs siRNA-NC.