Research Paper Volume 13, Issue 9 pp 13225—13238

TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways

Knockdown of TRIM14 induced melanoma cell cycle arrest. After transfection, both WM451 and A375 cells were collected for cell cycle distribution analysis using flow cytometry assay (A–B). The expression of cell cycle-related proteins (p21, cyclin D1, CDK2) were detected using western blot (C–D). ***p

Figure 4. Knockdown of TRIM14 induced melanoma cell cycle arrest. After transfection, both WM451 and A375 cells were collected for cell cycle distribution analysis using flow cytometry assay (AB). The expression of cell cycle-related proteins (p21, cyclin D1, CDK2) were detected using western blot (CD). ***p < 0.001 vs siRNA-NC.