Research Paper Volume 13, Issue 9 pp 13225—13238

TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways

TRIM14 overexpression enhanced melanoma cell migration and invasion through AKT and STAT3 pathways. After indicated treatment, the migration and invasion abilities of A375 cells were determined using wound-healing assay and Transwell assay, respectively (A–C). The protein expression of MMP2 and MMP9 was determined using western blot (D). Magnification ×100. ***p ##, ###p

Figure 8. TRIM14 overexpression enhanced melanoma cell migration and invasion through AKT and STAT3 pathways. After indicated treatment, the migration and invasion abilities of A375 cells were determined using wound-healing assay and Transwell assay, respectively (AC). The protein expression of MMP2 and MMP9 was determined using western blot (D). Magnification ×100. ***p < 0.001 vs Oe-NC; ##, ###p < 0.01, 0.001 vs Oe-TRIM14.