Research Paper Volume 13, Issue 9 pp 13225—13238

TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways

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Figure 8. TRIM14 overexpression enhanced melanoma cell migration and invasion through AKT and STAT3 pathways. After indicated treatment, the migration and invasion abilities of A375 cells were determined using wound-healing assay and Transwell assay, respectively (AC). The protein expression of MMP2 and MMP9 was determined using western blot (D). Magnification ×100. ***p < 0.001 vs Oe-NC; ##, ###p < 0.01, 0.001 vs Oe-TRIM14.