Research Paper Volume 13, Issue 10 pp 13941—13953

NEAT 1 knockdown enhances the sensitivity of human non-small-cell lung cancer cells to anlotinib

NEAT1 knockdown enhances the inhibitory effect of anlotinib on the proliferation of A549 and NCI-H1975 cells. Cells were treated with anlotinib (10 μM), NEAT1 siRNA 3 (10 nM), or the combination of anlotinib (10 μM) and NEAT1 siRNA 3 (10 nM) for 24 h. EdU staining was used to detect cell proliferation. (A) Cell proliferation in A549 cells and (B) NCI-H1975 cells. *P **P ##P

Figure 2. NEAT1 knockdown enhances the inhibitory effect of anlotinib on the proliferation of A549 and NCI-H1975 cells. Cells were treated with anlotinib (10 μM), NEAT1 siRNA 3 (10 nM), or the combination of anlotinib (10 μM) and NEAT1 siRNA 3 (10 nM) for 24 h. EdU staining was used to detect cell proliferation. (A) Cell proliferation in A549 cells and (B) NCI-H1975 cells. *P < 0.05, **P < 0.01 compared with the control group. ##P < 0.01, compared with the anlotinib group.