Research Paper Volume 13, Issue 10 pp 13941—13953

NEAT 1 knockdown enhances the sensitivity of human non-small-cell lung cancer cells to anlotinib

NEAT1 knockdown enhances the anti-apoptotic effect of anlotinib in A549 and NCI-H1975 cells. After 24 h of the indicated treatments, Annexin V and PI double staining was performed to detect cell apoptosis and the rate was quantified. (A) Cell apoptosis assays for A549 cells and (B) NCI-H1975 cells. **P ##P

Figure 4. NEAT1 knockdown enhances the anti-apoptotic effect of anlotinib in A549 and NCI-H1975 cells. After 24 h of the indicated treatments, Annexin V and PI double staining was performed to detect cell apoptosis and the rate was quantified. (A) Cell apoptosis assays for A549 cells and (B) NCI-H1975 cells. **P < 0.01 compared with the control group. ##P < 0.01, compared with the anlotinib group.